Pesquisa | Biblioteca Virtual em Saúde

1.

Propofol: Milk of Amnesia.

Walsh, Christopher T.

Cell ; 175(1): 10-13, 2018 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-30217361

2.

At the Intersection of Chemistry, Biology, and Medicine.

Walsh, Christopher T.

Annu Rev Biochem ; 86: 1-19, 2017 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-28125288

3.

Propofol: Milk of Amnesia.

Walsh, Christopher T.

Cell ; 185(25): 4861, 2022 Dec 08.

Artigo em Inglês | MEDLINE | ID: mdl-36493757

4.

Tailoring enzyme strategies and functional groups in biosynthetic pathways.

Walsh, Christopher T.

Nat Prod Rep ; 40(2): 326-386, 2023 02 22.

Artigo em Inglês | MEDLINE | ID: mdl-36268810

5.

Prospects for Antibacterial Discovery and Development.

Privalsky, Thomas M; Soohoo, Alexander M; Wang, Jinhua; Walsh, Christopher T; Wright, Gerard D; Gordon, Eric M; Gray, Nathanael S; Khosla, Chaitan.

J Am Chem Soc ; 143(50): 21127-21142, 2021 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-34860516

6.

Biologically generated carbon dioxide: nature's versatile chemical strategies for carboxy lyases.

Walsh, Christopher T.

Nat Prod Rep ; 37(1): 100-135, 2020 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-31074473

7.

Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.

Walsh, Christopher T; Tu, Benjamin P; Tang, Yi.

Chem Rev ; 118(4): 1460-1494, 2018 02 28.

Artigo em Inglês | MEDLINE | ID: mdl-29272116

8.

Oxidative Cyclization in Natural Product Biosynthesis.

Tang, Man-Cheng; Zou, Yi; Watanabe, Kenji; Walsh, Christopher T; Tang, Yi.

Chem Rev ; 117(8): 5226-5333, 2017 Apr 26.

Artigo em Inglês | MEDLINE | ID: mdl-27936626

9.

Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Dowling, Daniel P; Kung, Yan; Croft, Anna K; Taghizadeh, Koli; Kelly, Wendy L; Walsh, Christopher T; Drennan, Catherine L.

Proc Natl Acad Sci U S A ; 113(44): 12432-12437, 2016 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-27791103

10.

Enzymatic Cascade Reactions in Biosynthesis.

Walsh, Christopher T; Moore, Bradley S.

Angew Chem Int Ed Engl ; 58(21): 6846-6879, 2019 05 20.

Artigo em Inglês | MEDLINE | ID: mdl-30156048

11.

Recent Advances in Enzymatic Complexity Generation: Cyclization Reactions.

Walsh, Christopher T; Tang, Yi.

Biochemistry ; 57(22): 3087-3104, 2018 06 05.

Artigo em Inglês | MEDLINE | ID: mdl-29236467

12.

Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product.

Tran, Hai L; Lexa, Katrina W; Julien, Olivier; Young, Travis S; Walsh, Christopher T; Jacobson, Matthew P; Wells, James A.

J Am Chem Soc ; 139(7): 2541-2544, 2017 02 22.

Artigo em Inglês | MEDLINE | ID: mdl-28170244

13.

Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds?

Walsh, Christopher T.

Nat Prod Rep ; 34(7): 687-693, 2017 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-28513710

14.

Insights into the chemical logic and enzymatic machinery of NRPS assembly lines.

Walsh, Christopher T.

Nat Prod Rep ; 33(2): 127-35, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26175103

15.

The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds.

Malcolmson, Steven J; Young, Travis S; Ruby, J Graham; Skewes-Cox, Peter; Walsh, Christopher T.

Proc Natl Acad Sci U S A ; 110(21): 8483-8, 2013 May 21.

Artigo em Inglês | MEDLINE | ID: mdl-23650400

16.

Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution.

Tsodikov, Oleg V; Hou, Caixia; Walsh, Christopher T; Garneau-Tsodikova, Sylvie.

BMC Struct Biol ; 15: 13, 2015 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-26170207

17.

Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.

Lim, Fang Yun; Ames, Brian; Walsh, Christopher T; Keller, Nancy P.

Cell Microbiol ; 16(8): 1267-83, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-24612080

18.

Correction to: Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.

Walsh, Christopher T; Tu, Benjamin P; Tang, Yi.

Chem Rev ; 118(10): 5261-5263, 2018 05 23.

Artigo em Inglês | MEDLINE | ID: mdl-29620360

19.

Assembly line polyketide synthases: mechanistic insights and unsolved problems.

Khosla, Chaitan; Herschlag, Daniel; Cane, David E; Walsh, Christopher T.

Biochemistry ; 53(18): 2875-83, 2014 May 13.

Artigo em Inglês | MEDLINE | ID: mdl-24779441

20.

Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N-hydroxylase.

Setser, Jeremy W; Heemstra, John R; Walsh, Christopher T; Drennan, Catherine L.

Biochemistry ; 53(38): 6063-77, 2014 Sep 30.

Artigo em Inglês | MEDLINE | ID: mdl-25184411

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Propofol: Milk of Amnesia.

At the Intersection of Chemistry, Biology, and Medicine.

Propofol: Milk of Amnesia.

Tailoring enzyme strategies and functional groups in biosynthetic pathways.

Prospects for Antibacterial Discovery and Development.

Biologically generated carbon dioxide: nature's versatile chemical strategies for carboxy lyases.

Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.

Oxidative Cyclization in Natural Product Biosynthesis.

Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Enzymatic Cascade Reactions in Biosynthesis.

Recent Advances in Enzymatic Complexity Generation: Cyclization Reactions.

Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product.

Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds?

Insights into the chemical logic and enzymatic machinery of NRPS assembly lines.

The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds.

Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution.

Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.

Correction to: Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.

Assembly line polyketide synthases: mechanistic insights and unsolved problems.

Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N-hydroxylase.